Asymmetric malocclusions have always been a challenge to orthodontists, with different dental, skeletal, or dentoskeletal factors being probable causes for the condition. It is critically important to distinguish between dental and skeletal asymmetry before determining a predictable force system for corrective treatment. The use of mini-implants to address anchorage needs in modern orthodontic practice has become an important tool for orthodontists. The objective of this presentation is to present biomechanical concepts in which mini-implants are placed in the infra zygomatic crest (IZC) and buccal shelf (BS) areas for correction of dentofacial asymmetries allowing predictable outcomes to be achieved with minimal need for patient compliance and minor mechanical force side effects.